Ontology highlight
ABSTRACT:
SUBMITTER: Han X
PROVIDER: S-EPMC6107580 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Han Xuexiang X Li Yiye Y Xu Ying Y Zhao Xiao X Zhang Yinlong Y Yang Xiao X Wang Yongwei Y Zhao Ruifang R Anderson Gregory J GJ Zhao Yuliang Y Nie Guangjun G
Nature communications 20180823 1
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for anti-tumour therapy. Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, ...[more]