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Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury.


ABSTRACT: Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (MSC) research make MSCs a promising candidate for AKI management but relevant clinical trials show confusing results (NCT00733876, NCT01602328). One primary cause of the limited therapeutic effect may result from poor engraftment of transplanted cells. To solve this problem, investigators have developed a series of preconditioning strategies to improve MSC engraftment in animal AKI models. In this review, we summarize these previous studies, providing an integrated and updated view of different preconditioning strategies aimed at promoting the therapeutic effect of MSCs in AKI patients.

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6108125 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury.

Zhao Lingfei L   Hu Chenxia C   Zhang Ping P   Jiang Hua H   Chen Jianghua J  

Stem cell research & therapy 20180823 1


Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (MSC) research make MSCs a promising candidate for AKI management but relevant clinical trials show confusing results (NCT00733876, NCT01602328). One primary cause of the limited therapeutic effect may result from poor engraftment of transplanted cells. To solve this problem, investigators h  ...[more]

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