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Colistin Resistance Mediated by mcr-1 in ESBL-Producing, Multidrug Resistant Salmonella Infantis in Broiler Chicken Industry, Italy (2016-2017).


ABSTRACT: Colistin-resistance mediated by mobilisable and plasmid-borne mcr genes has emerged worldwide, threatening the efficacy of colistin, a last resort antibiotic increasingly used for treating human invasive infections by multidrug-resistant or extensively drug-resistant Enterobacteriaceae. In this study, we report the first evidence of mcr-1-mediated colistin resistance in four multidrug resistant (MDR) out of 324 Salmonella infantis from the Italian antimicrobial resistance (AMR) monitoring (2001-2017) in broilers and broiler meat. Two were also Extended Spectrum Beta-Lactamases (ESBL)-producing isolates. Characterization by whole genome sequencing (WGS), located mcr-1.1 on an incX4 plasmid. Phylogenetic analysis of these isolates with selected Italian S. Infantis previously isolated from animals, meat and human clinical cases with unknown epidemiological relationship, demonstrated that ESBL-producing, mcr-1-positive isolates belonged to the emerging pESI-like-positive-ESBL-producing clone described in Italy in 2015.

SUBMITTER: Carfora V 

PROVIDER: S-EPMC6108180 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Colistin Resistance Mediated by <i>mcr-1</i> in ESBL-Producing, Multidrug Resistant <i>Salmonella</i> Infantis in Broiler Chicken Industry, Italy (2016-2017).

Carfora Virginia V   Alba Patricia P   Leekitcharoenphon Pimlapas P   Ballarò Daniele D   Cordaro Gessica G   Di Matteo Paola P   Donati Valentina V   Ianzano Angela A   Iurescia Manuela M   Stravino Fiorentino F   Tagliaferri Tania T   Battisti Antonio A   Franco Alessia A  

Frontiers in microbiology 20180817


Colistin-resistance mediated by mobilisable and plasmid-borne <i>mcr</i> genes has emerged worldwide, threatening the efficacy of colistin, a last resort antibiotic increasingly used for treating human invasive infections by multidrug-resistant or extensively drug-resistant <i>Enterobacteriaceae</i>. In this study, we report the first evidence of <i>mcr</i>-1-mediated colistin resistance in four multidrug resistant (MDR) out of 324 <i>Salmonella</i> infantis from the Italian antimicrobial resist  ...[more]

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