Ontology highlight
ABSTRACT:
SUBMITTER: Qu Q
PROVIDER: S-EPMC6108936 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cell 20180809 5
The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS). The activity of the catalytic SET domain (su(var)3-9, enhancer-of-zeste, and trithorax) is endowed through forming a complex with a set of core proteins that are widely shared from yeast to humans. We obtained cryo-electron microscopy (cryo-EM) maps of the yeast Set1/COMPASS core complex at overall 4.0- to 4.4-Å ...[more]