Ontology highlight
ABSTRACT:
SUBMITTER: Awad D
PROVIDER: S-EPMC6108937 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Awad Dominik D Pulliam Thomas L TL Lin Chenchu C Wilkenfeld Sandi R SR Frigo Daniel E DE
Current opinion in pharmacology 20180330
Although androgen deprivation therapy (ADT) is initially effective for the treatment of progressive prostate cancer, it inevitably fails due to the onset of diverse resistance mechanisms that restore androgen receptor (AR) signaling. Thus, AR remains a desired therapeutic target even in the relapsed stages of the disease. Given the difficulties in stopping all AR reactivation mechanisms, we propose that the identification of the driver signaling events downstream of the receptor offer viable, al ...[more]