The UV/Visible Radiation Boundary Region (385-405?nm) Damages Skin Cells and Induces "dark" Cyclobutane Pyrimidine Dimers in Human Skin in vivo.

ABSTRACT: The adverse effects of terrestrial solar ultraviolet radiation (UVR) (~295-400?nm) on the skin are well documented, especially in the UVB region (~295-320?nm). The effects of very long-wave UVA (>380?nm) and visible radiation (?400?nm) are much less known. Sunscreens have been beneficial in inhibiting a wide range of photodamage, however most formulations provide very little protection in the long wave UVA region (380-400?nm) and almost none from shortwave visible wavelengths (400-420?nm). We demonstrate photodamage in this region for a number of different endpoints including cell viability, DNA damage (delayed cyclobutane pyrimidine dimers), differential gene expression (for genes associated with inflammation, oxidative stress and photoageing) and induction of oxidizing species in vitro in HaCaT keratinocytes and in vivo in human volunteers. This work has implications for phototherapy and photoprotection.

SUBMITTER: Lawrence KP 

PROVIDER: S-EPMC6109054 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature