Ontology highlight
ABSTRACT:
SUBMITTER: Heianza Y
PROVIDER: S-EPMC6109621 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
International journal of obesity (2005) 20180226 9
<h4>Background/objectives</h4>Gut microbiome regulates host energy metabolism and adiposity. A recent study identified a genome-wide significant variant in the lactase (LCT) gene that determines gut-microbiome abundance. We investigated whether the LCT variant influenced long-term changes in adiposity among overweight and obese individuals.<h4>Subjects/methods</h4>We included 583 whites with LCT variant rs4988235 (G allele as Bifidobacterium-abundance-increasing allele) who were randomly assigne ...[more]