Loss of IDO1 Expression From Human Pancreatic ?-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.
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ABSTRACT:
SUBMITTER: Anquetil F
PROVIDER: S-EPMC6110313 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.
Anquetil Florence F Mondanelli Giada G Gonzalez Nathaly N Rodriguez Calvo Teresa T Zapardiel Gonzalo Jose J Krogvold Lars L Dahl-Jørgensen Knut K Van den Eynde Benoit B Orabona Ciriana C Grohmann Ursula U von Herrath Matthias G MG
Diabetes 20180626 9
Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in β-cells from donors without diabetes, less IDO1 was expressed in insulin-containing islets from double autoantibody-positive donors and patients with recent-onset T1D, although it was virtually absen ...[more]
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