Ontology highlight
ABSTRACT:
SUBMITTER: Baker RL
PROVIDER: S-EPMC6110316 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Diabetes 20180705 9
We recently established that hybrid insulin peptides (HIPs), formed in islet β-cells by fusion of insulin C-peptide fragments to peptides of chromogranin A or islet amyloid polypeptide, are ligands for diabetogenic CD4 T-cell clones. The goal of this study was to investigate whether HIP-reactive T cells were indicative of ongoing autoimmunity. MHC class II tetramers were used to investigate the presence, phenotype, and function of HIP-reactive and insulin-reactive T cells in NOD mice. Insulin-re ...[more]