Ontology highlight
ABSTRACT:
SUBMITTER: Budhwani M
PROVIDER: S-EPMC6110817 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in oncology 20180821
The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs, radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I interferon (IFN) signaling for the promotion of both direct (tumor cell inhibition) and indirect (anti-tumor immune responses) effects. Malfunctions of this pathway in tumor cells or in immune cells may be responsible for the lack of response or resistance. Although type I IFN signaling is required to trigger anti-tumor im ...[more]