Ontology highlight
ABSTRACT:
SUBMITTER: Su H
PROVIDER: S-EPMC6111780 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Su Han H Li Shaopei S Terebiznik Mauricio M Guyard Cyril C Kerman Kagan K
Sensors (Basel, Switzerland) 20180814 8
The adhesin Legionella collagen-like (Lcl) protein can bind to extracellular matrix components and mediate the binding of <i>Legionella pneumophila</i> to host cells. In this study, electrochemical impedance spectroscopy (EIS) and surface plasmon resonance (SPR)-based biosensors were employed to characterize these interactions between glycosaminoglycans (GAGs) and the adhesin Lcl protein. Fucoidan displayed a high affinity (K<sub>D</sub> 18 nM) for Lcl protein. Chondroitin sulfate A and dermatan ...[more]