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Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs.


ABSTRACT: Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral recall responses via memory B cells are less well defined. In this article, we characterize a human tonsillar CD4+ T cell subset with this function. These cells are similar to Tfh cells in terms of expression of the chemokine receptor CXCR5 and the inhibitory receptor PD-1, IL-21 secretion, and expression of the transcription factor BCL6; however, unlike Tfh cells that are located within the B cell follicle and germinal center, they reside at the border of the T cell zone and the B cell follicle in proximity to memory B cells, a position dictated by their unique chemokine receptor expression. They promote memory B cells to produce Abs via CD40L, IL-10, and IL-21. Our results reveal a unique extrafollicular CD4+ T cell subset in human tonsils, which specialize in promoting T cell-dependent humoral recall responses.

SUBMITTER: Kim ST 

PROVIDER: S-EPMC6112860 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Human Extrafollicular CD4<sup>+</sup> Th Cells Help Memory B Cells Produce Igs.

Kim Sang Taek ST   Choi Jin-Young JY   Lainez Begona B   Schulz Vincent P VP   Karas David E DE   Baum Eric D ED   Setlur Jennifer J   Gallagher Patrick G PG   Craft Joe J  

Journal of immunology (Baltimore, Md. : 1950) 20180720 5


Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral recall responses via memory B cells are less well defined. In this article, we characterize a human tonsillar CD4<sup>+</sup> T cell subset with this function. These cells are similar to Tfh cells in terms of expression of the chemokine receptor CXCR5 and the inhibitory receptor PD-1, IL-21 secretion, and expression of the transcription fa  ...[more]

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