Ontology highlight
ABSTRACT:
SUBMITTER: Kim ST
PROVIDER: S-EPMC6112860 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kim Sang Taek ST Choi Jin-Young JY Lainez Begona B Schulz Vincent P VP Karas David E DE Baum Eric D ED Setlur Jennifer J Gallagher Patrick G PG Craft Joe J
Journal of immunology (Baltimore, Md. : 1950) 20180720 5
Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral recall responses via memory B cells are less well defined. In this article, we characterize a human tonsillar CD4<sup>+</sup> T cell subset with this function. These cells are similar to Tfh cells in terms of expression of the chemokine receptor CXCR5 and the inhibitory receptor PD-1, IL-21 secretion, and expression of the transcription fa ...[more]