Ontology highlight
ABSTRACT:
SUBMITTER: Ali M
PROVIDER: S-EPMC6113523 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ali Muhammad M Pulli Benjamin B Courties Gabriel G Tricot Benoit B Sebas Matthew M Iwamoto Yoshiko Y Hilgendorf Ingo I Schob Stefan S Dong Anping A Zheng Wei W Skoura Athanasia A Kalgukar Amit A Cortes Christian C Ruggeri Roger R Swirski Filip K FK Nahrendorf Matthias M Buckbinder Leonard L Chen John W JW
JACC. Basic to translational science 20161226 7
PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 days decreased the number of inflammatory cells and attenuated left ventricular dilation. Cardiac function and remodeling improved when treatment was increased to 21 days. Better therapeutic effect was further achieved with early compared with delayed treatment initiation (1 h vs. 24 h after infarction). In conclusion, ...[more]