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Caspase-10 is an initiator caspase in death receptor signaling.

ABSTRACT: A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.

SUBMITTER: Wang J

PROVIDER: S-EPMC61136 | biostudies-literature | 2001 Nov

REPOSITORIES: biostudies-literature

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Caspase-10 is an initiator caspase in death receptor signaling.

Wang J J Chun H J HJ Wong W W Spencer D M DM Lenardo M J MJ

Proceedings of the National Academy of Sciences of the United States of America 20011101 24

A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the ...[more]

PMID: 11717445

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