Ontology highlight
ABSTRACT:
SUBMITTER: Lin CJ
PROVIDER: S-EPMC6114144 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Lin Ching-Jung CJ Hu Fuqu F Dubruille Raphaelle R Vedanayagam Jeffrey J Wen Jiayu J Smibert Peter P Loppin Benjamin B Lai Eric C EC
Developmental cell 20180801 3
Intragenomic conflicts are fueled by rapidly evolving selfish genetic elements, which induce selective pressures to innovate opposing repressive mechanisms. This is patently manifest in sex-ratio (SR) meiotic drive systems, in which distorter and suppressor factors bias and restore equal transmission of X and Y sperm. Here, we reveal that multiple SR suppressors in Drosophila simulans (Nmy and Tmy) encode related hairpin RNAs (hpRNAs), which generate endo-siRNAs that repress the paralogous disto ...[more]