Ontology highlight
ABSTRACT:
SUBMITTER: Martini V
PROVIDER: S-EPMC6114956 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Martini Veronica V Frezzato Federica F Severin Filippo F Raggi Flavia F Trimarco Valentina V Martinello Leonardo L Molfetta Rosa R Visentin Andrea A Facco Monica M Semenzato Gianpietro G Paolini Rossella R Trentin Livio L
Oncotarget 20180814 63
Abnormalities of molecules involved in signal transduction pathways are connected to Chronic Lymphocytic Leukemia (CLL) pathogenesis and a critical role has been already ascribed to B-Cell Receptor (BCR)-Lyn axis. E3 ubiquitin ligase c-Cbl, working together with adapter protein CIN85, controls the degradation of protein kinases involved in BCR signaling. To investigate cell homeostasis in CLL, we studied c-Cbl since in normal B cells it is involved in the ubiquitin-dependent Lyn degradation and ...[more]