Ontology highlight
ABSTRACT:
SUBMITTER: Gill MK
PROVIDER: S-EPMC6115388 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Gill Mandeep K MK Christova Tania T Zhang Ying Y YY Gregorieff Alex A Zhang Liang L Narimatsu Masahiro M Song Siyuan S Xiong Shawn S Couzens Amber L AL Tong Jiefei J Krieger Jonathan R JR Moran Michael F MF Zlotta Alexandre R AR van der Kwast Theodorus H TH Gingras Anne-Claude AC Sicheri Frank F Wrana Jeffrey L JL Attisano Liliana L
Nature communications 20180829 1
In most solid tumors, the Hippo pathway is inactivated through poorly understood mechanisms that result in the activation of the transcriptional regulators, YAP and TAZ. Here, we identify NUAK2 as a YAP/TAZ activator that directly inhibits LATS-mediated phosphorylation of YAP/TAZ and show that NUAK2 induction by YAP/TAZ and AP-1 is required for robust YAP/TAZ signaling. Pharmacological inhibition or loss of NUAK2 reduces the growth of cultured cancer cells and mammary tumors in mice. Moreover, i ...[more]