Ontology highlight
ABSTRACT:
SUBMITTER: Ducuing A
PROVIDER: S-EPMC4298692 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Ducuing Antoine A Keeley Charlotte C Mollereau Bertrand B Vincent Stéphane S
The Journal of cell biology 20150101 2
Development is robust because nature has selected various mechanisms to buffer the deleterious effects of environmental and genetic variations to deliver phenotypic stability. Robustness relies on smart network motifs such as feed-forward loops (FFLs) that ensure the reliable interpretation of developmental signals. In this paper, we show that Decapentaplegic (DPP) and JNK form a coherent FFL that controls the specification and differentiation of leading edge cells during Drosophila melanogaster ...[more]