Pervasive Modulation of Obesity Risk by the Environment and Genomic Background.
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ABSTRACT:
SUBMITTER: Nagpal S
PROVIDER: S-EPMC6115725 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Pervasive Modulation of Obesity Risk by the Environment and Genomic Background.
Nagpal Sini S Gibson Greg G Marigorta Urko M UM
Genes 20180814 8
The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a major role for environmental risk factors. Obesity constitutes a case example of a modern trait shaped by contemporary environment, although with considerable debates about the extent ...[more]
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