Ontology highlight
ABSTRACT:
SUBMITTER: McCloskey CW
PROVIDER: S-EPMC6115831 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
McCloskey Curtis W CW Rodriguez Galaxia M GM Galpin Kristianne J C KJC Vanderhyden Barbara C BC
Cancers 20180726 8
Immunotherapy has emerged as one of the most promising approaches for ovarian cancer treatment. The tumor microenvironment (TME) is a key factor to consider when stimulating antitumoral responses as it consists largely of tumor promoting immunosuppressive cell types that attenuate antitumor immunity. As our understanding of the determinants of the TME composition grows, we have begun to appreciate the need to address both inter- and intra-tumor heterogeneity, mutation/neoantigen burden, immune l ...[more]