Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC6115971 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Ye Jody J Gillespie Kathleen M KM Rodriguez Santiago S
Genes 20180727 8
Although genome-wide association studies (GWAS) have identified several hundred loci associated with autoimmune diseases, their mechanistic insights are still poorly understood. The human genome is more complex than single nucleotide polymorphisms (SNPs) that are interrogated by GWAS arrays. Apart from SNPs, it also comprises genetic variations such as insertions-deletions, copy number variations, and somatic mosaicism. Although previous studies suggest that common copy number variations do not ...[more]