Ontology highlight
ABSTRACT:
SUBMITTER: Hiramitsu S
PROVIDER: S-EPMC6116707 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Hiramitsu Shiro S Ishikawa Tomonori T Lee Wan-Ru WR Khan Tamor T Crumbley Christine C Khwaja Nimra N Zamanian Faezeh F Asghari Arvand A Sen Mehmet M Zhang Yang Y Hawse John R JR Minna John D JD Umetani Michihisa M
Frontiers in endocrinology 20180823
27-hydroxycholesterol (27HC) is an abundant cholesterol metabolite in human circulation and promotes breast cancer cell proliferation. Although lung is one of the organs that contain high levels of 27HC, the role of 27HC in lung is unknown. In this study, we found that 27HC promotes lung cancer cell proliferation in an estrogen receptor β (ERβ)-dependent manner. The expression of 27HC-generating enzyme CYP27A1 is higher in lung cancer cells than in normal lung cells. Treatment with 27HC increase ...[more]