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Association between refrigerator use and the risk of gastric cancer: A systematic review and meta-analysis of observational studies.

ABSTRACT: There were many observational studies that examined the association between refrigerator use and stomach cancer. However, the results remain to be a contradiction. This study aimed to evaluate the association between refrigerator use and the risk of gastric cancer. We systematically searched the PubMed, Embase, Web of Science databases (up to 31 May 2017), and manually reviewed the references lists of retrieved articles, to identify studies that evaluated the association between refrigerator use and the risk of gastric cancer. Observational studies reporting odds ratio (OR) with 95% confidence intervals (CIs) for the relationship between refrigerator use and the risk of gastric cancer were included. Two authors independently reviewed and selected eligible studies and conducted the study quality evaluation. We included a total of twelve studies enrolling 14,361 individuals. The summarized OR the association between refrigerator use and the risk of gastric cancer was 0.70 (95% CI, 0.56-0.88; P<0.001). Subgroup analysis showed that a significantly inverse association between refrigerator use and gastric cancer risk was observed in in some Asian countries (OR = 0.68, 95% CI, 0.50-0.93; P = 0.002), but not in some Western countries, such as Germany, etc. Refrigerator use is significantly associated with a decreased risk of gastric cancer. Further studies are warranted to confirm whether refrigerator use could reduce the risk of gastric cancer among some Asian countries.

SUBMITTER: Yan S

PROVIDER: S-EPMC6117033 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Project description:PURPOSE:The aim was to compare fatigue levels between patients with visual impairment and controls with normal sight and to examine the association between fatigue and vision loss severity. METHODS:A systematic literature search was performed using databases of PubMed, Embase, PsycINFO and Cochrane to identify observational studies with outcomes related to fatigue (e.g. vitality subscale of the Short-Form 36, Fatigue Assessment Scale). A meta-analysis was performed using standardised mean differences (SMDs) and odds ratios (OR) to quantitatively summarise the association between visual impairment and fatigue. Sources of heterogeneity were explored by subgroup and sensitivity analyses. Study quality was assessed with the Newcastle-Ottawa scale. RESULTS:After reviewing 4477 studies, 22 studies with a total of 40 004 participants were included, of which 18 contributed to meta-analysis. Among these, eight were assessed as moderate quality studies and 10 as high quality studies. Pooled analysis involving 2500 patients and 8395 controls showed higher fatigue severity levels (S.M.D. = -0.36, 95% CI -0.50 to -0.22, 14 studies) among visually impaired patients compared to normally sighted controls. This effect size was small and persisted in sensitivity analyses that involved study quality, fatigue assessment tools and visual acuity data. Furthermore, pooled analysis of four studies including 2615 patients and 5438 controls showed a significant association between visual impairment and fatigue (OR = 2.61, 95% CI 1.69 to 4.04). Secondary meta-analysis of four studies showed no significant difference in fatigue severity (S.M.D. = 0.01, 95% CI -0.37 to 0.39) between patients with moderate visual impairment and patients with severe visual impairment or blindness. CONCLUSIONS:Current moderate to high quality evidence suggest that patients with visual impairment experience more severe fatigue symptoms than persons with normal sight. However, a limited number of available studies indicates that fatigue is not associated with severity of vision loss. Future studies are required to determine which factors and underlying mechanisms may explain the association between visual impairment and fatigue. Discussing fatigue at an early stage and developing intervention options for vision-related fatigue should be considered within the field of low vision rehabilitation.

Project description:This systematic review and meta-analysis examines the associations of allergic rhinitis with sleep duration and sleep impairment. Observational studies published before August 2019 were obtained through English language literature searches in the PubMed, Embase, and CINAHL databases. Mean differences and odds ratios with 95% confidence intervals were extracted and used for meta-analysis. Heterogeneity was confirmed by the I2-heterogeneity test. Subgroup analysis was conducted to evaluate the influence of study design. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to determine the level of evidence. In total, 2544 records were identified through database searches; 914 duplicate records were excluded, 1452 records were removed after screening of titles and abstracts, 151 records were excluded after full-text screening, and 27 articles were included in the final meta-analyses. A total of 240,706,026 patients (19,444,043 with allergic rhinitis) were considered. No significant difference in sleep duration between the allergic rhinitis and the control groups was found. Patients with allergic rhinitis presented with significantly higher sleep quality scores, sleep disturbances scores, and sleep latency scores; more frequent use of sleep medications; and lower sleep efficiency as measured by the Pittsburgh Sleep Quality Index and polysomnography. Meta-analyses for adjusted odds ratios showed that allergic rhinitis was also associated with higher risks of nocturnal dysfunctions, including insomnia, nocturnal enuresis, restless sleep, sleep-disordered breathing, obstructive sleep apnea, and snoring. Meta-analysis for adjusted odds ratio also showed that allergic rhinitis was associated with daytime dysfunction, including difficulty waking up, daytime sleepiness, morning headache, and the use of sleep medications. The overall quality of evidence ranged from low to very low, indicating that caution is required when interpreting these results. This study demonstrates that there is a significant association of AR with sleep characteristics.

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Association between refrigerator use and the risk of gastric cancer: A systematic review and meta-analysis of observational studies.

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