Ontology highlight
ABSTRACT:
SUBMITTER: Kim AY
PROVIDER: S-EPMC6117269 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kim Ah-Young AY Lee Eun-Mi EM Lee Eun-Joo EJ Kim Jae-Hong JH Suk Kyoungho K Lee Eunhye E Hur Keun K Hong Yean Ju YJ Do Jeong Tae JT Park SunYoung S Jeong Kyu-Shik KS
Cell death & disease 20180830 9
The role of sirtuins (SIRTs) in cancer biology has been the focus of recent research. The similarities between underlying pathways involved in the induction of pluripotent stem cells and transformation of cancer cells revealed the role of SIRTs in cellular reprogramming. Seven SIRTs have been identified in mammals and downregulation of SIRT2 was found to facilitate the generation of primed pluripotent stem cells, such as human induced pluripotent stem cells. Herein, we evaluated the role of SIRT ...[more]