Ontology highlight
ABSTRACT:
SUBMITTER: Pandian GN
PROVIDER: S-EPMC3408130 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Pandian Ganesh N GN Nakano Yusuke Y Sato Shinsuke S Morinaga Hironobu H Bando Toshikazu T Nagase Hiroki H Sugiyama Hiroshi H
Scientific reports 20120730
Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown to artificially induce epigenetic modifications in a sequence independent manner. Recently, we showed that specific DNA binding hairpin pyrrole-imidazole polyamides (PIPs) could be conjugated with chromatin modifying histone deacetylase inhibitors like SAHA to epigenetically activate certain pluripotent genes in mouse ...[more]