Ontology highlight
ABSTRACT:
SUBMITTER: Kaddurah-Daouk R
PROVIDER: S-EPMC6118295 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kaddurah-Daouk Rima R Hankemeier Thomas T Scholl Elizabeth H EH Baillie Rebecca R Harms Amy A Stage Claus C Dalhoff Kim P KP Jűrgens Gesche G Taboureau Olivier O Nzabonimpa Grace S GS Motsinger-Reif Alison A AA Thomsen Ragnar R Linnet Kristian K Rasmussen Henrik B HB
CPT: pharmacometrics & systems pharmacology 20180801 8
Carboxylesterase 1 (CES1) metabolizes methylphenidate and other drugs. CES1 gene variation only partially explains pharmacokinetic (PK) variability. Biomarkers predicting the PKs of drugs metabolized by CES1 are needed. We identified lipids in plasma from 44 healthy subjects that correlated with CES1 activity as determined by PK parameters of methylphenidate including a ceramide (q value = 0.001) and a phosphatidylcholine (q value = 0.005). Carriers of the CES1 143E allele had decreased methylph ...[more]