Encoding canonical DNA quadruplex structure.
Ontology highlight
ABSTRACT:
SUBMITTER: Dvorkin SA
PROVIDER: S-EPMC6118410 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Encoding canonical DNA quadruplex structure.
Dvorkin Scarlett A SA Karsisiotis Andreas I AI Webba da Silva Mateus M Webba da Silva Mateus M
Science advances 20180831 8
The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its multiple, repetitive guanine segments. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications. ...[more]
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