Ontology highlight
ABSTRACT:
SUBMITTER: Lomidze L
PROVIDER: S-EPMC8829921 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Lomidze Levan L Yang Mengkun M Khutsishvili David D Metreveli Nunu N Musier-Forsyth Karin K Kankia Besik B
ACS omega 20220126 5
We previously reported a tetrahelical monomolecular architecture of DNA, tmDNA, which employs G-quartets and an all-parallel GGGTGGGTGGGTGGG (G3T) quadruplex as the repeating unit. Based on thermodynamic and kinetic studies, we proposed that covalently joined (G3T) <i><sub>n</sub></i> units formed an uninterrupted programmable homopolymer; however, structural evidence for the tmDNA architecture was lacking. Here, we used NMR spectroscopy of wild-type and single-inosine-substituted constructs to ...[more]