Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC6118634 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wu Hao H Rahman H N Ashiqur HNA Dong Yunzhou Y Liu Xiaolei X Lee Yang Y Wen Aiyun A To Kim Ht KH Xiao Li L Birsner Amy E AE Bazinet Lauren L Wong Scott S Song Kai K Brophy Megan L ML Mahamud M Riaj MR Chang Baojun B Cai Xiaofeng X Pasula Satish S Kwak Sukyoung S Yang Wenxia W Bischoff Joyce J Xu Jian J Bielenberg Diane R DR Dixon J Brandon JB D'Amato Robert J RJ Srinivasan R Sathish RS Chen Hong H
The Journal of clinical investigation 20180813 9
Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this pathway is affected in diabetes remains poorly understood. We previously demonstrated that loss of epsins 1 and 2 in lymphatic endothelial cells (LECs) prevented VEGF-C-induced VEGFR3 from endocytosis and degradation. Here, we report that diabetes attenuated VEGF-C-induced lymphangiogenesis in corneal micropocket and Matrigel plug assays i ...[more]