Ontology highlight
ABSTRACT:
SUBMITTER: Davis JA
PROVIDER: S-EPMC6054491 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Davis Jennifer A JA Koenig Andrew L AL Lubert Allison A Chestnut Brendan B Liu Fang F Palencia Desai Sharina S Winkler Tamara T Pociute Karolina K Choi Kyunghee K Sumanas Saulius S
Developmental biology 20180509 1
The molecular mechanisms initiating the formation of the lymphatic system, lymphangiogenesis, are still poorly understood. Here we have identified a novel role in lymphangiogenesis for an ETS transcription factor, Etv2/Etsrp, a known regulator of embryonic vascular development. Through the use of fully validated photoactivatable morpholinos we show that inducible Etv2 inhibition in zebrafish embryos at 1 day post-fertilization (dpf) results in significant inhibition of lymphangiogenesis, while d ...[more]