Ontology highlight
ABSTRACT:
SUBMITTER: Miao D
PROVIDER: S-EPMC6119118 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Miao Diana D Margolis Claire A CA Vokes Natalie I NI Liu David D Taylor-Weiner Amaro A Wankowicz Stephanie M SM Adeegbe Dennis D Keliher Daniel D Schilling Bastian B Tracy Adam A Manos Michael M Chau Nicole G NG Hanna Glenn J GJ Polak Paz P Rodig Scott J SJ Signoretti Sabina S Sholl Lynette M LM Engelman Jeffrey A JA Getz Gad G Jänne Pasi A PA Haddad Robert I RI Choueiri Toni K TK Barbie David A DA Haq Rizwan R Awad Mark M MM Schadendorf Dirk D Hodi F Stephen FS Bellmunt Joaquim J Wong Kwok-Kin KK Hammerman Peter P Van Allen Eliezer M EM
Nature genetics 20180827 9
Tumor mutational burden correlates with response to immune checkpoint blockade in multiple solid tumors, although in microsatellite-stable tumors this association is of uncertain clinical utility. Here we uniformly analyzed whole-exome sequencing (WES) of 249 tumors and matched normal tissue from patients with clinically annotated outcomes to immune checkpoint therapy, including radiographic response, across multiple cancer types to examine additional tumor genomic features that contribute to se ...[more]