Ontology highlight
ABSTRACT:
SUBMITTER: Cloughesy TF
PROVIDER: S-EPMC6120351 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cloughesy Timothy F TF Landolfi Joseph J Vogelbaum Michael A MA Ostertag Derek D Elder James B JB Bloomfield Stephen S Carter Bob B Chen Clark C CC Kalkanis Steven N SN Kesari Santosh S Lai Albert A Lee Ian Y IY Liau Linda M LM Mikkelsen Tom T Nghiemphu Phioanh P Piccioni David D Accomando William W Diago Oscar R OR Hogan Daniel J DJ Gammon Dawn D Kasahara Noriyuki N Kheoh Thian T Jolly Douglas J DJ Gruber Harry E HE Das Asha A Walbert Tobias T
Neuro-oncology 20180901 10
<h4>Background</h4>Vocimagene amiretrorepvec (Toca 511) is an investigational gamma-retroviral replicating vector encoding cytosine deaminase that, when used in combination with extended-release 5-fluorocytosine (Toca FC), results preclinically in local production of 5-fluorouracil, depletion of immune-suppressive myeloid cells, and subsequent induction of antitumor immunity. Recurrent high-grade glioma (rHGG) patients have a high unmet need for effective therapies that produce durable responses ...[more]