Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13 C experiments.

ABSTRACT: PURPOSE:To investigate the feasibility of performing large FOV hyperpolarized 13 C metabolic imaging using simultaneous multislice excitation. METHODS:A spectral-spatial multislice excitation pulse was constructed by cosine modulation and incorporated into a 13 C spiral imaging sequence. Phantom and in vivo pig experiments were performed to test the feasibility of simultaneous multislice data acquisition and image reconstruction. In vivo cardiac-gated images of hyperpolarized pyruvate, bicarbonate, and lactate were obtained at 1?×?1?×?1?cm3 resolution over a 48?×?48?×?24?cm3 FOV with 2-fold acceleration in the slice direction. Sensitivity encoding was used for image reconstruction with both autocalibrated and numerically calculated coil sensitivities. RESULTS:Simultaneous multislice images obtained with 2-fold acceleration were comparable to reference unaccelerated images. Retained SNR figures greater than 80% were achieved over the part of the image containing the heart. CONCLUSION:This method is anticipated to enable large FOV imaging studies using hyperpolarized 13 C substrates, with an aim toward whole-body exams that have to date been out of reach.

SUBMITTER: Lau AZ 

PROVIDER: S-EPMC6120460 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature