Dataset Information

Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [¹³ C,¹⁵ N₂ ]urea + [1-¹³ C]pyruvate simultaneous perfusion and metabolic imaging.

ABSTRACT:

Purpose

This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized ¹³ C-MRI human study with injection of co-hyperpolarized [1-¹³ C]pyruvate and [¹³ C,¹⁵ N₂ ]urea.

Methods

A metabolite-specific bSSFP urea imaging sequence was designed using a urea-specific excitation pulse, optimized TR, and 3D stack-of-spiral readouts. Simulations and phantom studies were performed to validate the spectral response of the sequence. The image quality of urea data acquired by the 3D-bSSFP sequence and the 2D-GRE sequence was evaluated with 2 identical injections of co-hyperpolarized [1-¹³ C]pyruvate and [¹³ C,¹⁵ N₂ ]urea formula in a rat. Subsequently, the feasibility of the acquisition strategy was validated in a prostate cancer patient.

Results

Simulations and phantom studies demonstrated that 3D-bSSFP sequence achieved urea-only excitation, while minimally perturbing other metabolites (<1%). An animal study demonstrated that compared to GRE, bSSFP sequence provided an ∼2.5-fold improvement in SNR without perturbing urea or pyruvate kinetics, and bSSFP approach with a shorter spiral readout reduced blurring artifacts caused by J-coupling of [¹³ C,¹⁵ N₂ ]urea. The human study demonstrated the in vivo feasibility and data quality of the acquisition strategy.

Conclusion

The 3D-bSSFP urea sequence with a stack-of-spiral acquisition demonstrated significantly increased SNR and image quality for [¹³ C,¹⁵ N₂ ]urea in co-hyperpolarized [1-¹³ C]pyruvate and [¹³ C,¹⁵ N₂ ]urea imaging studies. This work lays the foundation for future human studies to achieve high-quality and high-SNR metabolism and perfusion images.

SUBMITTER: Liu X

PROVIDER: S-EPMC9810116 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging.

Liu Xiaoxi X Tang Shuyu S Mu Changhua C Qin Hecong H Cui Di D Lai Ying-Chieh YC Riselli Andrew M AM Delos Santos Romelyn R Carvajal Lucas L Gebrezgiabhier Daniel D Bok Robert A RA Chen Hsin-Yu HY Flavell Robert R RR Gordon Jeremy W JW Vigneron Daniel B DB Kurhanewicz John J Larson Peder E Z PEZ

Magnetic resonance in medicine 20220508 3

<h4>Purpose</h4>This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized 13 C-MRI human study with injection of co-hyperpolarized [1-13 C]pyruvate and [13 C,15 N2 ]urea. ...[more]

PMID: 35526263

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