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Regiospecific N-Arylation of Aliphatic Amines under Mild and Metal-Free Reaction Conditions.

ABSTRACT: A transition metal-free N-arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N-alkyl anilines. The methodology is unprecedented among metal-free methods in terms of amine scope, the ability to transfer both electron-withdrawing and electron-donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required.

SUBMITTER: Purkait N

PROVIDER: S-EPMC6120470 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Regiospecific N-Arylation of Aliphatic Amines under Mild and Metal-Free Reaction Conditions.

Purkait Nibadita N Kervefors Gabriella G Linde Erika E Olofsson Berit B

Angewandte Chemie (International ed. in English) 20180726 35

A transition metal-free N-arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N-alkyl anilines. The methodology is unprecedented among metal-free methods in terms of amine scope, the ability to transfer both electron-withdrawing and electron-donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required. ...[more]

PMID: 29956877

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