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Genetic variation of hepatitis B surface antigen among acute and chronic hepatitis B virus infections in The Netherlands.


ABSTRACT: Genetic variation within hepatitis B surface antigen (HBsAg), in particular within the major hydrophobic region (MHR), is related to immune/vaccine and test failures and can have a significant impact on the vaccination and diagnosis of acute infection. This study shows, for the first time, variation among acute cases and compares the amino acid variation within the HBsAg between acute and chronic infections. We analyzed the virus isolated from 1231 acute and 585 chronic cases reported to an anonymized public health surveillance database between 2004 and 2014 in The Netherlands. HBsAg analysis revealed the circulation of 6 genotypes (Gt); GtA was the dominant genotype followed by GtD among both acute (68.2% and 17.4%, respectively) and chronic (34.9% and 34.2%, respectively) cases. Variation was the highest among chronic strains compared to that among acute strains. Both acute and chronic GtD showed the highest variation compared to that of other genotypes (P?

SUBMITTER: Cremer J 

PROVIDER: S-EPMC6120544 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Genetic variation of hepatitis B surface antigen among acute and chronic hepatitis B virus infections in The Netherlands.

Cremer Jeroen J   Hofstraat Sanne H I SHI   van Heiningen Francoise F   Veldhuijzen Irene K IK   van Benthem Birgit H B BHB   Benschop Kimberley S M KSM  

Journal of medical virology 20180607 10


Genetic variation within hepatitis B surface antigen (HBsAg), in particular within the major hydrophobic region (MHR), is related to immune/vaccine and test failures and can have a significant impact on the vaccination and diagnosis of acute infection. This study shows, for the first time, variation among acute cases and compares the amino acid variation within the HBsAg between acute and chronic infections. We analyzed the virus isolated from 1231 acute and 585 chronic cases reported to an anon  ...[more]

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