Ontology highlight
ABSTRACT:
SUBMITTER: Cremer J
PROVIDER: S-EPMC6120544 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cremer Jeroen J Hofstraat Sanne H I SHI van Heiningen Francoise F Veldhuijzen Irene K IK van Benthem Birgit H B BHB Benschop Kimberley S M KSM
Journal of medical virology 20180607 10
Genetic variation within hepatitis B surface antigen (HBsAg), in particular within the major hydrophobic region (MHR), is related to immune/vaccine and test failures and can have a significant impact on the vaccination and diagnosis of acute infection. This study shows, for the first time, variation among acute cases and compares the amino acid variation within the HBsAg between acute and chronic infections. We analyzed the virus isolated from 1231 acute and 585 chronic cases reported to an anon ...[more]