Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6120676 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Chemistry (Weinheim an der Bergstrasse, Germany) 20180515 31
The disruption of copper homeostasis and the oxidative stress induced by Cu-amyloids are crucial features of Alzheimer's disease pathology. The copper specific N<sub>4</sub> -tetradendate ligands TDMQ20 and 1 are able to fully inhibit in vitro the aerobic oxidation of ascorbate induced by Cu-Aβ<sub>1-16</sub> , even in the presence of 100 molar equivalents of Zn<sup>II</sup> with respect to Cu<sup>II</sup> , whereas other ligands with N<sub>2</sub> O<sub>2</sub> or N<sub>3</sub> O<sub>2</sub> co ...[more]