A novel DCL2-dependent miRNA pathway in tomato affects susceptibility to RNA viruses.
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ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC6120711 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
A novel DCL2-dependent miRNA pathway in tomato affects susceptibility to RNA viruses.
Wang Zhengming Z Hardcastle Thomas J TJ Canto Pastor Alex A Yip Wing Hin WH Tang Shuoya S Baulcombe David C DC
Genes & development 20180827 17-18
Tomato Dicer-like2 (slDCL2) is a key component of resistance pathways against potato virus X (PVX) and tobacco mosaic virus (TMV). It is also required for production of endogenous small RNAs, including miR6026 and other noncanonical microRNAs (miRNAs). The <i>slDCL</i>2 mRNAs are targets of these slDCL2-dependent RNAs in a feedback loop that was disrupted by target mimic RNAs of miR6026. In lines expressing these RNAs, there was correspondingly enhanced resistance against PVX and TMV. These find ...[more]
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