Ontology highlight
ABSTRACT:
SUBMITTER: Takashita E
PROVIDER: S-EPMC6291754 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Takashita Emi E Morita Hiroko H Ogawa Rie R Nakamura Kazuya K Fujisaki Seiichiro S Shirakura Masayuki M Kuwahara Tomoko T Kishida Noriko N Watanabe Shinji S Odagiri Takato T
Frontiers in microbiology 20181206
The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza A and B virus infections in February 2018 in Japan. Because of the need to monitor influenza viruses for reduced susceptibility to this drug, we used two cell-based screening systems - a conventional plaque reduction assay and a focus reduction assay - to evaluate the susceptibility of influenza viruses to baloxavir. First, we generated a reference virus possessing an I38T substitution i ...[more]