Ontology highlight
ABSTRACT:
SUBMITTER: Mphahlele MJ
PROVIDER: S-EPMC6121530 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20180731 8
A series of indole-aminoquinazolines was prepared via amination of the 2-aryl-4-chloroquinazolines with the 7-amino-2-aryl-5-bromoindoles. It was then evaluated for cytotoxicity in vitro against human lung cancer (A549), epithelial colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A), breast adenocarcinoma (MCF-7), and cervical cancer (HeLa) cells. A combination on the quinazoline and indole moieties of a 2-phenyl and 2-(4-fluorophenyl) rings in compound <b>4b</b>; 2-(4-fluoropheny ...[more]