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Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives.


ABSTRACT: A cobalt-catalyzed C(sp2)-H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group.

SUBMITTER: Han JN 

PROVIDER: S-EPMC6122339 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Cobalt-catalyzed <i>peri</i>-selective alkoxylation of 1-naphthylamine derivatives.

Han Jiao-Na JN   Du Cong C   Zhu Xinju X   Wang Zheng-Long ZL   Zhu Yue Y   Chu Zhao-Yang ZY   Niu Jun-Long JL   Song Mao-Ping MP  

Beilstein journal of organic chemistry 20180809


A cobalt-catalyzed C(sp<sup>2</sup>)-H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after  ...[more]

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