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A Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines.

ABSTRACT: A new cobalt catalyst is presented for the domino hydroformylation-reductive amination reaction of olefins. The optimal Co-tert-BuPy-Xantphos catalyst shows good to excellent linear-to-branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.

SUBMITTER: Yang J

PROVIDER: S-EPMC9299624 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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A Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines.

Yang Ji J Delolo Fábio G FG Spannenberg Anke A Jackstell Ralf R Beller Matthias M

Angewandte Chemie (International ed. in English) 20211202 2

A new cobalt catalyst is presented for the domino hydroformylation-reductive amination reaction of olefins. The optimal Co-tert-BuPy-Xantphos catalyst shows good to excellent linear-to-branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts. ...[more]

PMID: 34738697

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