Ontology highlight
ABSTRACT:
SUBMITTER: Durand-de Cuttoli R
PROVIDER: S-EPMC6122951 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
eLife 20180904
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors. Yet the temporal dynamic range and mechanism of action of acetylcholine (ACh) on the modulation of VTA circuits and reward-related behaviors are not known. Here, we used a chemical-genetic approach for rapid and precise optical manipulation of nicotinic neurotransmission in VTA neurons in living mice. We provide direct evidence that the ...[more]