Ontology highlight
ABSTRACT:
SUBMITTER: Stuber GD
PROVIDER: S-EPMC2613864 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Stuber Garret D GD Klanker Marianne M de Ridder Bram B Bowers M Scott MS Joosten Ruud N RN Feenstra Matthijs G MG Bonci Antonello A
Science (New York, N.Y.) 20080901 5896
Using sensory information for the prediction of future events is essential for survival. Midbrain dopamine neurons are activated by environmental cues that predict rewards, but the cellular mechanisms that underlie this phenomenon remain elusive. We used in vivo voltammetry and in vitro patch-clamp electrophysiology to show that both dopamine release to reward predictive cues and enhanced synaptic strength onto dopamine neurons develop over the course of cue-reward learning. Increased synaptic s ...[more]