Ontology highlight
ABSTRACT:
SUBMITTER: Cohen YZ
PROVIDER: S-EPMC6122972 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cohen Yehuda Z YZ Lorenzi Julio C C JCC Krassnig Lisa L Barton John P JP Burke Leah L Pai Joy J Lu Ching-Lan CL Mendoza Pilar P Oliveira Thiago Y TY Sleckman Christopher C Millard Katrina K Butler Allison L AL Dizon Juan P JP Belblidia Shiraz A SA Witmer-Pack Maggi M Shimeliovich Irina I Gulick Roy M RM Seaman Michael S MS Jankovic Mila M Caskey Marina M Nussenzweig Michel C MC
The Journal of experimental medicine 20180802 9
A clinical trial was performed to evaluate 3BNC117, a potent anti-HIV-1 antibody, in infected individuals during suppressive antiretroviral therapy and subsequent analytical treatment interruption (ATI). The circulating reservoir was evaluated by quantitative and qualitative viral outgrowth assay (Q<sup>2</sup>VOA) at entry and after 6 mo. There were no significant quantitative changes in the size of the reservoir before ATI, and the composition of circulating reservoir clones varied in a manner ...[more]