Ontology highlight
ABSTRACT:
SUBMITTER: Lu CL
PROVIDER: S-EPMC6275529 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lu Ching-Lan CL Pai Joy A JA Nogueira Lilian L Mendoza Pilar P Gruell Henning H Oliveira Thiago Y TY Barton John J Lorenzi Julio C C JCC Cohen Yehuda Z YZ Cohn Lillian B LB Klein Florian F Caskey Marina M Nussenzweig Michel C MC Jankovic Mila M
Proceedings of the National Academy of Sciences of the United States of America 20181112 48
Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented by a variety of methods, most prominently by viral outgrowth assays (VOAs) in which CD4<sup>+</sup> T cells are activated to produce virus in vitro, or more recently by amplifying proviral near full-length (NFL) sequences from DNA. Analysis of s ...[more]