Ontology highlight
ABSTRACT:
SUBMITTER: Singh MD
PROVIDER: S-EPMC6122975 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Singh Mark D MD Ni Minjian M Sullivan Jenna M JM Hamerman Jessica A JA Campbell Daniel J DJ
The Journal of experimental medicine 20180809 9
CD8<sup>+</sup> T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell ada ...[more]