Ontology highlight
ABSTRACT:
SUBMITTER: Griffith OL
PROVIDER: S-EPMC6123466 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180904 1
Here we report targeted sequencing of 83 genes using DNA from primary breast cancer samples from 625 postmenopausal (UBC-TAM series) and 328 premenopausal (MA12 trial) hormone receptor-positive (HR+) patients to determine interactions between somatic mutation and prognosis. Independent validation of prognostic interactions was achieved using data from the METABRIC study. Previously established associations between MAP3K1 and PIK3CA mutations with luminal A status/favorable prognosis and TP53 mut ...[more]