Ontology highlight
ABSTRACT:
SUBMITTER: Smith C
PROVIDER: S-EPMC6123622 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Smith Chad C Frolinger Tal T Brathwaite Justin J Sims Steven S Pasinetti Giulio M GM
Communications biology 20180503
Grape-derived polyphenols have been investigated for their role in promoting memory in model systems of stress, but little is known about select subpopulations of neurons that are influenced by polyphenols to improve memory performance. Granule neurons in the hippocampal dentate gyrus are vulnerable to stressors that impair contextual memory function and can be influenced by dietary polyphenols. We utilized a c-fos-tTA/TRE-ChR2 optogenetics model in which neurons activated during fear learning a ...[more]