Ontology highlight
ABSTRACT:
SUBMITTER: Costa-Machado LF
PROVIDER: S-EPMC6123659 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Costa-Machado Luis Filipe LF Martín-Hernández Roberto R Sanchez-Luengo Miguel Ángel MÁ Hess Katharina K Vales-Villamarin Claudia C Barradas Marta M Lynch Cian C de la Nava Daniel D Diaz-Ruiz Alberto A de Cabo Rafael R Cañamero Marta M Martinez Lola L Sanchez-Carbayo Marta M Herranz Daniel D Serrano Manuel M Fernandez-Marcos Pablo J PJ
EMBO reports 20180718 9
The NAD<sup>+</sup>-dependent deacetylase SIRT1 can be oncogenic or tumor suppressive depending on the tissue. Little is known about the role of SIRT1 in non-small cell lung carcinoma (NSCLC), one of the deadliest cancers, that is frequently associated with mutated K-RAS Therefore, we investigated the effect of SIRT1 on K-RAS-driven lung carcinogenesis. We report that SIRT1 protein levels are downregulated by oncogenic K-RAS in a MEK and PI3K-dependent manner in mouse embryo fibroblasts (MEFs), ...[more]